Endocrine Abstracts

Context: The influence of beta cell replacement on daily glucose profile in Type 1 diabetes mellitus (T1DM) is not firmly established.Objective: To examine the influence of islet transplantation (IT) on the various component of dysglycemia in T1DM patients.Design, setting and patients: Single arm open labeled study. Twenty-three consecutive patients with T1DM, 11 males and 12 females, 14 non uremic and 9 uremic with a previous kidn...

Glucocorticoid metabolism is altered in a tissue-specific manner in obesity. Increased reactivation of glucocorticoids by 11beta-hydroxysteroid dehydrogenase type 1 (11HSD1) amplifies glucocorticoid action in abdominal fat, whereas increased metabolism of glucocorticoids by hepatic A-ring reductases may contribute to activation of the hypothalamic-pituitary-adrenal axis. These changes have been characterised in leptin-resistant obese Zucker rats and obese humans. Here we inves...